Thalidomide

Thalidomide was a drug that was prescribed to pregnant women in the tardily 1950s and early 1960s to help combat come home complaint. It effectively reduced the symptoms of morning sickness in those women, notwithstanding at a horrible cost. Many of the children born from women who took Thalidomide dudoughnut motherhood were born with give defects and were c each(prenominal)ed Thalidomide babies. In reference to the stereochemistry of Thalidomide, in that respect is barely one chiral carbon, and thus just rudimentary isomers. Thalidomide exists in cardinal stereoisomers, S-thalidomide, which is a sedative that calms nervousness, and R-thalidomide, which was found to be a teratogen that causes birth defects. The carbon atom from the carbon-nitrogen bond connecting the two main ring structures is chiral, as shown on the attached premium paper. The R-thalidomide isomer is the one that causes all the problems with birth defects, so one great power think that if the S-tha lidomide isomer was disposed to patients instead, there wouldnt prevail been such(prenominal) a dread(a) problem. That, however, isnt the case. Humans convert the S-thalidomide into R-thalidomide once in the body, so it really doesnt matter which enantiomer is taken, it would produce toxic effects to the babies of the pregnant women anyway.

Although the use of Thalidomide for morning sickness and its libellous effects to the babies has been called one of the biggest medical tragedies of modern propagation, there was some good to come from finding the worse results. The Thalidomide calamity led to much strict er testing being mandatory for drugs and pes! ticides before they can be licensed. In addition, it has been found to be a viable treatment for many medical conditions including treble myeloma in people who have been recently found to have this disease. Its also used to treat and prevent shinny symptoms of erythema nodosum leprosum(ENL or leprosy).If you want to get a full essay, prescribe it on our website: BestEssayCheap.com

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